Consider using application level checksums

From this 1999 document titled When The CRC and TCP Checksum Disagree, analysing abnormous rates of errors in network transfers.

Our conclusion is that vital applications should strongly consider augmenting the TCP checksum with an application sum.

Even if you're not concerned with security, it maybe wise to implement an MD5 check (or like) at the application level for your multi-gigs file transfer before you start processing them.

Source: slashdot.